Maintenance Dose Calculation

Introduction to Maintenance Dose Calculation

The maintenance dose (MD) calculation is used in pharmacology to determine the necessary dosage to maintain a target steady-state plasma concentration (Css) of a drug. The formula utilizes the concepts of the volume of distribution (Vd) and clearance (Cl) of the drug to calculate the maintenance dose. This is important for ensuring that the drug remains at a therapeutic concentration in the body over time.

Parameter usage:

• Css = steady-state plasma concentration of the drug
• Vd = volume of distribution of the drug
• Cl = clearance of the drug
• MD = maintenance dose of the drug

Data validation

The steady-state plasma concentration (Css) should be a positive number. The volume of distribution (Vd) and clearance (Cl) should also be positive numbers.

Summary

This calculator assists in determining the maintenance dose required to achieve and maintain a specific concentration of a drug in the body, utilizing principles of pharmacokinetics.