Hepatic Clearance (Well-Stirred Model)

Introduction to Hepatic Clearance using Well-Stirred Model

Hepatic Clearance (CL) using the Well-Stirred Model is a pharmacokinetic concept used to describe the efficiency of the liver in removing a drug from the blood. The formula calculates hepatic clearance based on the blood flow to the liver (Q), the drug concentration in the blood (C), the drug extraction ratio (E), and the volume of distribution (V).

Parameters:

• Q = blood flow to liver (ml/min)
• C = drug concentration in blood (mg/ml)
• E = extraction ratio (-)
• V = volume of distribution (ml)

Output:

• CL = hepatic clearance (ml/min)

Data Validation

All parameters should be greater than zero. Extraction ratio should be between 0 and 1.

Summary

This calculator provides the hepatic clearance of a drug based on its pharmacokinetic parameters, aiding in understanding its metabolism and potential dosing adjustments.