Bioavailability Formula
Formula:F = (AUCoral / AUCiv) × 100
Introduction to Bioavailability Formula
The bioavailability formula calculates the percentage of a drug that reaches the systemic circulation when administered through the oral route compared to the intravenous route. In this formula, F represents bioavailability, AUCoral is the area under the plasma concentration-time curve after oral administration, and AUCiv is the area under the plasma concentration-time curve after intravenous administration. The result is expressed as a percentage.
Parameter usage:
AUCoral= area under the plasma concentration-time curve after oral administrationAUCiv= area under the plasma concentration-time curve after intravenous administration
Output:
F= bioavailability percentage
Data validation
The AUC values should be positive numbers.
Summary
This formula is used in pharmacology to determine the bioavailability of a drug when administered via different routes.