# Das Verständnis der Bioverfügbarkeitsformel in der Pharmakologie

**Formula:**`FA = (AUCpo / AUCiv) * (DoseIv / DosePo) * 100`

## Understanding the Bioavailability Formula

Bioavailability is a crucial pharmacokinetic parameter that determines the extent and rate at which an active drug ingredient or therapeutic moiety is absorbed from a drug product and becomes available at the site of action. Let's delve into the intricacies of the bioavailability formula and understand how each component affects the overall calculation.

## Bioavailability Formula Breakdown

The bioavailability (FA) is calculated using the formula:

`FA = (AUCpo / AUCiv) * (DoseIv / DosePo) * 100`

### Parameters:

`AUCpo`

= Area Under the Curve for oral administration (measured in mg·h/L)`AUCiv`

= Area Under the Curve for intravenous administration (measured in mg·h/L)`DosePo`

= Dose of the drug when given orally (measured in mg)`DoseIv`

= Dose of the drug when given intravenously (measured in mg)

### Outputs:

`FA`

= Bioavailability of the drug (expressed in percentage %)

The AUC represents the drug concentration in the blood over time, and comparing AUCpo to AUCiv helps determine the proportion of the drug that reaches systemic circulation.

## Real-life Example

Suppose a patient takes a 100mg dose of a drug orally (DosePo), and the AUCpo is measured to be 50 mg·h/L. The same patient is given a 10mg dose of the drug intravenously (DoseIv), and the AUCiv is found to be 25 mg·h/L. The bioavailability (FA) is calculated as follows:

`FA = (50 / 25) * (10 / 100) * 100`

Calculating step-by-step:

`50 / 25 = 2`

`10 / 100 = 0.1`

`2 * 0.1 = 0.2`

`0.2 * 100 = 20%`

Thus, the bioavailability of this drug when taken orally is 20%.

## Data Validation

Bioavailability calculations require carefully measured inputs to ensure accuracy. Here are some rules to validate the data:

**Non-negative Values:**Ensure all inputs (AUCpo, AUCiv, DosePo, DoseIv) are greater than zero.**Measurement Units:**Ensure consistent measurement units to avoid calculation errors.

## Summary

Bioavailability is a vital metric in pharmacology, influencing drug formulation and therapeutic effectiveness. Accurate measurement and calculation ensure proper drug dosing and patient safety. Understanding and calculating bioavailability allows healthcare providers to make informed decisions regarding drug administration routes and dosing schedules.

### Frequently Asked Questions (FAQs)

#### What is the significance of bioavailability?

Bioavailability determines the proportion of a drug that reaches the systemic circulation, which impacts its therapeutic effect.

#### Why is AUC used in the bioavailability formula?

AUC represents the total drug exposure over time, helping compare different administration routes.

#### How does bioavailability affect drug dosing?

A drug with low bioavailability requires a higher oral dose compared to intravenous administration to achieve the same effect.

Tags: Pharmakologie, Bioverfügbarkeit, Arzneimittelabsorption